Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy

Jingjing Han, Hyunchul Kang, Xingshu Li, Nahyun Kwon, Haidong Li, Sungnam Park, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photofenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 × 1011 s-1 versus 1.17 × 106 s-1), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fenton-like activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.

Original languageEnglish
Pages (from-to)5954-5962
Number of pages9
JournalACS Applied Nano Materials
Volume4
Issue number6
DOIs
StatePublished - 25 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

Keywords

  • Fe(II)-coordination-driven Co-assembly
  • ferrotherapeutic agent
  • photosensitive nanoparticles
  • photosensitizer
  • self-evolution

Fingerprint

Dive into the research topics of 'Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy'. Together they form a unique fingerprint.

Cite this