Phosphorylcholine-Based Zwitterionic Biocompatible Thermogel

Du Young Ko, Madhumita Patel, Bo Kyoeng Jung, Jin Hye Park, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Zwitterionic polymers have been investigated as surface-coating materials due to their low protein adsorption properties, which reduce immunogenicity, biofouling, and bacterial adsorption of coated materials. Most zwitterionic polymers, reported so far, are based on (meth)acrylate polymers which can induce toxicity by residual monomers or amines produced by degradation. Here, we report a new zwitterionic polymer consisting of phosphorylcholine (PC) and biocompatible poly(propylene glycol) (PPG) as a new thermogelling material. The PC-PPG-PC polymer aqueous solution undergoes unique multiple sol-gel transitions as the temperature increases. A heat-induced unimer-to-micelle transition, changes in ionic interactions, and dehydration of PPG are involved in the sol-gel transitions. Based on the broad gel window and low protein adsorption properties, the PC-PPG-PC thermogel is proved for sustained delivery of protein drugs and stem cells over 1 week.

Original languageEnglish
Pages (from-to)3853-3862
Number of pages10
JournalBiomacromolecules
Volume16
Issue number12
DOIs
StatePublished - 14 Dec 2015

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