Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp

Hiyoung Kim; Jungwook Chin; Hyukjae Choi; Kyungryul Baek; Tae Gu Lee; Seong Eon Park; Weihong Wang; Dongyup Hahn; Inho Yang; Jihye Lee; Bora Mun; Merrick Ekins; Sang Jip Nam; Heonjoong Kang

doi:10.1021/ol3031318

Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp

Hiyoung Kim
, Jungwook Chin
, Hyukjae Choi
, Kyungryul Baek
, Tae Gu Lee
, Seong Eon Park
, Weihong Wang
, Dongyup Hahn
, Inho Yang
, Jihye Lee
, Bora Mun
, Merrick Ekins
, Sang Jip Nam
, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC₅₀ of 23.7 nM.

Original language	English
Pages (from-to)	100-103
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	1
DOIs	https://doi.org/10.1021/ol3031318
State	Published - 4 Jan 2013

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10.1021/ol3031318

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title = "Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp",

abstract = "Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC50 of 23.7 nM.",

author = "Hiyoung Kim and Jungwook Chin and Hyukjae Choi and Kyungryul Baek and Lee, \{Tae Gu\} and Park, \{Seong Eon\} and Weihong Wang and Dongyup Hahn and Inho Yang and Jihye Lee and Bora Mun and Merrick Ekins and Nam, \{Sang Jip\} and Heonjoong Kang",

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day = "4",

doi = "10.1021/ol3031318",

language = "English",

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TY - JOUR

T1 - Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp

AU - Kim, Hiyoung

AU - Chin, Jungwook

AU - Choi, Hyukjae

AU - Baek, Kyungryul

AU - Lee, Tae Gu

AU - Park, Seong Eon

AU - Wang, Weihong

AU - Hahn, Dongyup

AU - Yang, Inho

AU - Lee, Jihye

AU - Mun, Bora

AU - Ekins, Merrick

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2013/1/4

Y1 - 2013/1/4

N2 - Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC50 of 23.7 nM.

AB - Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC50 of 23.7 nM.

UR - https://www.scopus.com/pages/publications/84874070706

U2 - 10.1021/ol3031318

DO - 10.1021/ol3031318

M3 - Article

C2 - 23240782

AN - SCOPUS:84874070706

SN - 1523-7060

VL - 15

SP - 100

EP - 103

JO - Organic Letters

JF - Organic Letters

IS - 1

ER -

Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp

Abstract

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