Abstract
Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC50 of 23.7 nM.
Original language | English |
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Pages (from-to) | 100-103 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - 4 Jan 2013 |