Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge placospongia sp

Hiyoung Kim, Jungwook Chin, Hyukjae Choi, Kyungryul Baek, Tae Gu Lee, Seong Eon Park, Weihong Wang, Dongyup Hahn, Inho Yang, Jihye Lee, Bora Mun, Merrick Ekins, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC50 of 23.7 nM.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalOrganic Letters
Volume15
Issue number1
DOIs
StatePublished - 4 Jan 2013

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