Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Yehee Lee; Weihong Wang; Hiyoung Kim; Awadut G. Giri; Dong Hwan Won; Dongyup Hahn; Kyung Ryul Baek; Jihye Lee; Inho Yang; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1016/j.bmcl.2014.07.066

Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Yehee Lee
, Weihong Wang
, Hiyoung Kim
, Awadut G. Giri
, Dong Hwan Won
, Dongyup Hahn
, Kyung Ryul Baek
, Jihye Lee
, Inho Yang
, Hyukjae Choi
, Sang Jip Nam
, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC₅₀ = 11.4 μM).

Original language	English
Pages (from-to)	4095-4098
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2014.07.066
State	Published - 1 Sep 2014

Bibliographical note

Funding Information:
This study was supported by the Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea, and Suncheon Research Center for Natural Medicines.

Keywords

Cytotoxicity
Phorbaketals
Phorbas sp.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2014.07.066

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title = "Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas",

abstract = "Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50 = 11.4 μM).",

keywords = "Cytotoxicity, Phorbaketals, Phorbas sp.",

author = "Yehee Lee and Weihong Wang and Hiyoung Kim and Giri, \{Awadut G.\} and Won, \{Dong Hwan\} and Dongyup Hahn and Baek, \{Kyung Ryul\} and Jihye Lee and Inho Yang and Hyukjae Choi and Nam, \{Sang Jip\} and Heonjoong Kang",

note = "Funding Information: This study was supported by the Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea, and Suncheon Research Center for Natural Medicines. ",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.bmcl.2014.07.066",

language = "English",

volume = "24",

pages = "4095--4098",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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TY - JOUR

T1 - Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

AU - Lee, Yehee

AU - Wang, Weihong

AU - Kim, Hiyoung

AU - Giri, Awadut G.

AU - Won, Dong Hwan

AU - Hahn, Dongyup

AU - Baek, Kyung Ryul

AU - Lee, Jihye

AU - Yang, Inho

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

N1 - Funding Information: This study was supported by the Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea, and Suncheon Research Center for Natural Medicines.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50 = 11.4 μM).

AB - Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50 = 11.4 μM).

KW - Cytotoxicity

KW - Phorbaketals

KW - Phorbas sp.

UR - https://www.scopus.com/pages/publications/84906940249

U2 - 10.1016/j.bmcl.2014.07.066

DO - 10.1016/j.bmcl.2014.07.066

M3 - Article

C2 - 25124114

AN - SCOPUS:84906940249

SN - 0960-894X

VL - 24

SP - 4095

EP - 4098

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Abstract

Bibliographical note

Keywords

UN SDGs

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