Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Yehee Lee, Weihong Wang, Hiyoung Kim, Awadut G. Giri, Dong Hwan Won, Dongyup Hahn, Kyung Ryul Baek, Jihye Lee, Inho Yang, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50 = 11.4 μM).

Original languageEnglish
Pages (from-to)4095-4098
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number17
DOIs
StatePublished - 1 Sep 2014

Keywords

  • Cytotoxicity
  • Phorbaketals
  • Phorbas sp.

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