Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation

Mi Ran Byun, A. Rum Kim, Jun Ha Hwang, Mi Kyung Sung, Yeon Kyung Lee, Buyng Su Hwang, Jung Rae Rho, Eun Sook Hwang, Jeong Ho Hong

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60 Scopus citations


Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK. Structured summary of protein interactions: TAZ physically interacts with RUNX2 by pull down (View interaction).

Original languageEnglish
Pages (from-to)1086-1092
Number of pages7
JournalFEBS Letters
Issue number8
StatePublished - 24 Apr 2012

Bibliographical note

Funding Information:
This work was supported by basic science research programs (2007-0053654 and 2011-0022926) and the BRL program (2009-0001197) through the National Research Foundation of Korea (NRF) and a Grant from the Marine Biotechnology Program funded by the Land, Transport and Maritime Affairs, Republic of Korea.


  • Differentiation
  • ERK
  • Osteoblast
  • Phorbaketal A
  • TAZ


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