Pharmacotherapy against oxidative stress in chronic kidney disease: Promising small molecule natural products targeting nrf2-ho-1 signaling

Md Jamal Uddin, Ee Hyun Kim, Md Abdul Hannan, Hunjoo Ha

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney protection by regulating antioxidants during OS. Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. Thus, activation of Nrf2-HO-1 signaling may offer a potential approach to the design of novel therapeutic agents for kidney diseases. In this review, we have discussed the association between OS and the pathogenesis of CKD. We propose Nrf2-HO-1 signaling-mediated cell survival systems be explored as pharmacological targets for the treatment of CKD and have reviewed the literature on the beneficial effects of small molecule natural products that may provide protection against CKD.

Original languageEnglish
Article number258
Pages (from-to)1-26
Number of pages26
JournalAntioxidants
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Chronic kidney diseases
  • HO-1
  • Nrf2
  • Oxidative stress
  • Small molecule natural products

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