Pharmacokinetics and pharmacodynamics of ketoprofen plasters

Sung Koun Heo, Jeiwon Cho, Ji Woong Cheon, Min Koo Choi, Dong Soon Im, Jung Ju Kim, Yang Gyu Choi, Do Yong Jeon, Suk Jae Chung, Chang Koo Shim, Dae Duk Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Ketoprofen plasters of 70 cm2 size using DuroTak® acrylic adhesive polymers were developed either containing 30 mg (Ketotop-L) or 60 mg drug (Ketotop-P). The in vitro skin permeation profile was obtained in hairless mouse skin and showed the permeation rate of Ketotop-P to be twice that of Ketotop-L. The plasma concentration profile of ketoprofen was determined in Sprague-Dawley rats after applying a 3 × 3 cm2 plaster. AUC0-24h and Cmax of Ketotop-P were 260.92 μg · h/ml and 25.09 μg/ml, respectively, which were about twice the values of Ketotop-L. The hind paw edema induced by carrageenan injection was measured for 6 h after applying a 2 × 2 cm2 plaster, and the area under the time-response curve (AUR) value was significantly lower in Ketotop-P attached rats (180.70% · h) than in those with the Ketotop-L (298.65% · h) and the control (407.04% · h) groups, indicating a stronger anti-inflammatory action of Ketotop-P. However, the analgesic effect of the two formulations did not show a statistically significant difference. In conclusion, Ketotop-P was able to achieve higher plasma concentration of ketoprofen, thereby exhibiting higher and more constant anti-inflammatory effect compared with Ketotop-L.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalBiopharmaceutics and Drug Disposition
Issue number1
StatePublished - Jan 2008


  • Analgesic
  • Anti-inflammation
  • Ketoprofen
  • Pharmacodynamics
  • Pharmacokinetics
  • Plaster


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