Pharmacokinetic alteration of paclitaxel by ferulic acid derivative

Jaeok Lee, Song Wha Chae, Lianji Ma, So Yeon Lim, Sarah Alnajjar, Hea Young Park Choo, Hwa Jeong Lee, Sandy Jeong Rhie

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs.

Original languageEnglish
Article number593
Issue number11
StatePublished - Nov 2019


  • Bioavailability
  • Elimination
  • Ferulic acid derivatives
  • P-glycoprotein
  • Paclitaxel
  • Pharmacokinetics


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