PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko; Sangjin Park; Hyejung Lee; Heebeom Koo; Min Sang Kim; Kuiwon Choi; Ick Chan Kwon; Seo Young Jeong; Kwangmeyung Kim; Doo Sung Lee

doi:10.1002/smll.201001252

PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko, Sangjin Park, Hyejung Lee, Heebeom Koo, Min Sang Kim, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwangmeyung Kim, Doo Sung Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

Original language	English
Pages (from-to)	2539-2544
Number of pages	6
Journal	Small
Volume	6
Issue number	22
DOIs	https://doi.org/10.1002/smll.201001252
State	Published - 22 Nov 2010

Keywords

block copolymers
fluorescent probes
micelles
nanoparticles
tumor imaging

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10.1002/smll.201001252

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title = "PH-sensitive nanoflash for tumoral acidic pH imaging in live animals",

abstract = "Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.",

keywords = "block copolymers, fluorescent probes, micelles, nanoparticles, tumor imaging",

author = "Ko, {Jin Young} and Sangjin Park and Hyejung Lee and Heebeom Koo and Kim, {Min Sang} and Kuiwon Choi and Kwon, {Ick Chan} and Jeong, {Seo Young} and Kwangmeyung Kim and Lee, {Doo Sung}",

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doi = "10.1002/smll.201001252",

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AU - Ko, Jin Young

AU - Park, Sangjin

AU - Lee, Hyejung

AU - Koo, Heebeom

AU - Kim, Min Sang

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Jeong, Seo Young

AU - Kim, Kwangmeyung

AU - Lee, Doo Sung

PY - 2010/11/22

Y1 - 2010/11/22

N2 - Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

AB - Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

KW - block copolymers

KW - fluorescent probes

KW - micelles

KW - nanoparticles

KW - tumor imaging

UR - http://www.scopus.com/inward/record.url?scp=78649666582&partnerID=8YFLogxK

U2 - 10.1002/smll.201001252

DO - 10.1002/smll.201001252

M3 - Article

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VL - 6

SP - 2539

EP - 2544

JO - Small

JF - Small

IS - 22

ER -

PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Abstract

Keywords

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