pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim; Jong Ho Kim; Kwangmeyung Kim; Yoo Shin Kim; Rang Woon Park; In San Kim; Ick Chan Kwon; Doo Sung Lee

doi:10.1016/j.ijpharm.2006.09.027

pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim
, Jong Ho Kim
, Kwangmeyung Kim
, Yoo Shin Kim
, Rang Woon Park
, In San Kim
, Ick Chan Kwon
, Doo Sung Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/j.ijpharm.2006.09.027
State	Published - 22 Feb 2007

Bibliographical note

Funding Information:
This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science & Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program.

Keywords

In vivo anti-tumor effect
Injectable hydrogel
Paclitaxel
TUNEL assay
pH/T-sensitive block copolymer hydrogel

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10.1016/j.ijpharm.2006.09.027

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@article{dc7d9e9b78534252bcea1851ebb87a71,

title = "pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel",

abstract = "Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.",

keywords = "In vivo anti-tumor effect, Injectable hydrogel, Paclitaxel, TUNEL assay, pH/T-sensitive block copolymer hydrogel",

author = "Shim, \{Woo Sun\} and Kim, \{Jong Ho\} and Kwangmeyung Kim and Kim, \{Yoo Shin\} and Park, \{Rang Woon\} and Kim, \{In San\} and Kwon, \{Ick Chan\} and Lee, \{Doo Sung\}",

note = "Funding Information: This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science \& Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program.",

year = "2007",

month = feb,

day = "22",

doi = "10.1016/j.ijpharm.2006.09.027",

language = "English",

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journal = "International Journal of Pharmaceutics",

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T1 - pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

AU - Shim, Woo Sun

AU - Kim, Jong Ho

AU - Kim, Kwangmeyung

AU - Kim, Yoo Shin

AU - Park, Rang Woon

AU - Kim, In San

AU - Kwon, Ick Chan

AU - Lee, Doo Sung

N1 - Funding Information: This work was supported by grant no. R01-2006-000-10629-0 from the Basic Research Program of the Korean Science & Engineering Foundation and Real-Time Imaging project of KIST Intramural Research Program.

PY - 2007/2/22

Y1 - 2007/2/22

N2 - Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

AB - Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

KW - In vivo anti-tumor effect

KW - Injectable hydrogel

KW - Paclitaxel

KW - TUNEL assay

KW - pH/T-sensitive block copolymer hydrogel

UR - https://www.scopus.com/pages/publications/33846573824

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DO - 10.1016/j.ijpharm.2006.09.027

M3 - Article

C2 - 17049773

AN - SCOPUS:33846573824

SN - 0378-5173

VL - 331

SP - 11

EP - 18

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1

ER -

pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Abstract

Bibliographical note

Keywords

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