Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata

Yun Seo Kil; Seong Min Kim; Unwoo Kang; Hae Young Chung; Eun Kyoung Seo

doi:10.1021/acs.jnatprod.7b00139

Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata

Yun Seo Kil
, Seong Min Kim
, Unwoo Kang
, Hae Young Chung
, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO^-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC₅₀ values in the range 0.14-2.2 μM.

Original language	English
Pages (from-to)	2240-2251
Number of pages	12
Journal	Journal of Natural Products
Volume	80
Issue number	8
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00139
State	Published - 25 Aug 2017

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Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.

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title = "Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata",

abstract = "Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.",

author = "Kil, \{Yun Seo\} and Kim, \{Seong Min\} and Unwoo Kang and Chung, \{Hae Young\} and Seo, \{Eun Kyoung\}",

note = "Publisher Copyright: {\textcopyright} 2017 The American Chemical Society and American Society of Pharmacognosy.",

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month = aug,

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doi = "10.1021/acs.jnatprod.7b00139",

language = "English",

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T1 - Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata

AU - Kil, Yun Seo

AU - Kim, Seong Min

AU - Kang, Unwoo

AU - Chung, Hae Young

AU - Seo, Eun Kyoung

PY - 2017/8/25

Y1 - 2017/8/25

N2 - Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.

AB - Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata

Abstract

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