TY - JOUR
T1 - Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata
AU - Kil, Yun Seo
AU - Kim, Seong Min
AU - Kang, Unwoo
AU - Chung, Hae Young
AU - Seo, Eun Kyoung
N1 - Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2017/8/25
Y1 - 2017/8/25
N2 - Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.
AB - Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6′-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7′S,8′R)-lariciresinol 9′-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.
UR - http://www.scopus.com/inward/record.url?scp=85028298362&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00139
DO - 10.1021/acs.jnatprod.7b00139
M3 - Article
C2 - 28787158
AN - SCOPUS:85028298362
SN - 0163-3864
VL - 80
SP - 2240
EP - 2251
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 8
ER -