Peroxiredoxin 2 deletion impairs hippocampal-dependent memory via exacerbating transient ischemia-induced oxidative damage

Yoon Sun Jang, Yo Seob Lee, Dong Hee Kim, Goo Taeg Oh, Won Kyung Jeon, Jung Soo Han

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Peroxiredoxin 2 (Prx2) regulates oxidative stress response in neuronal injury. The present study examined the effects of Prx2 deletion on transient global ischemia-induced hippocampal-dependent memory impairment. First, 20-min bilateral common carotid artery occlusion (BCCAO)-reperfusion and sham-operated control procedures were conducted in 6- or 7-month-old Prx2 knockout and wild-type mice. The cognitive status of these mice was assessed using the Morris water maze task with a hidden platform and a novel object recognition task 7 days after the 20-min BCCAO. Next, to evaluate neuronal degeneration and oxidative stress in the CA1 subregion of the hippocampus critical for learning and memory, we measured immunoreactive Fluoro-jade C (FJC)-positive signals and 4-hydroxy-2-trans-nonenal (4-HNE) levels, respectively. The 20-min BCCAO induced cognitive impairments and increased the intensity of FJC-positive signals and 4-HNE levels of CA1 in Prx2 knockout mice but not in wild-type mice. These results suggest that Prx2 deficiency reduces resilience to transient global ischemia.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalBrain Research Bulletin
StatePublished - 15 Jun 2022

Bibliographical note

Funding Information:
This work was financially supported by grants from the National Research Council of Science and Technology (NST) by the Korean government (MSIP) ( CRC-15-04-KIST , KSN1621850 , and NSN1522380 ) and the Korea Research Foundation funded by the Korean Government ( NRF-2020R1A2C1005148 and 2020M3E5D9080734 to J.S.H.). This paper was also supported by the Konkuk University Researcher Fund in 2020.

Publisher Copyright:
© 2022 Elsevier Inc.


  • Hippocampus
  • Memory
  • Mice
  • Peroxiredoxin 2
  • Transient global ischemia


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