Performance IQ in children is associated with blood cadmium concentration in early pregnancy

Kyoung Sook Jeong; Hyewon Park; Eunhee Ha; Yun Chul Hong; Mina Ha; Hyesook Park; Bung Nyun Kim; Bo Eun Lee; Soo Jeong Lee; Kyung Yeon Lee; Ja Hyeong Kim; Yangho Kim

doi:10.1016/j.jtemb.2014.11.007

Performance IQ in children is associated with blood cadmium concentration in early pregnancy

Kyoung Sook Jeong, Hyewon Park, Eunhee Ha, Yun Chul Hong, Mina Ha, Hyesook Park, Bung Nyun Kim, Bo Eun Lee, Soo Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Yangho Kim

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50 Scopus citations

Abstract

Objective: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Method: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Results: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Conclusion: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	Journal of Trace Elements in Medicine and Biology
Volume	30
DOIs	https://doi.org/10.1016/j.jtemb.2014.11.007
State	Published - 1 Apr 2015

Bibliographical note

Funding Information:
This study was supported by MOCEH (Mothers and Children's Environmental Health) project funded by the National Institute of Environmental Research , Republic of Korea.

Publisher Copyright:
© 2014 Elsevier GmbH.

Keywords

Blood cadmium
IQ
Performance
WPPSI-R

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10.1016/j.jtemb.2014.11.007

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title = "Performance IQ in children is associated with blood cadmium concentration in early pregnancy",

abstract = "Objective: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Method: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Results: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Conclusion: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.",

keywords = "Blood cadmium, IQ, Performance, WPPSI-R",

author = "Jeong, {Kyoung Sook} and Hyewon Park and Eunhee Ha and Hong, {Yun Chul} and Mina Ha and Hyesook Park and Kim, {Bung Nyun} and Lee, {Bo Eun} and Lee, {Soo Jeong} and Lee, {Kyung Yeon} and Kim, {Ja Hyeong} and Yangho Kim",

note = "Funding Information: This study was supported by MOCEH (Mothers and Children's Environmental Health) project funded by the National Institute of Environmental Research , Republic of Korea. Publisher Copyright: {\textcopyright} 2014 Elsevier GmbH.",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.jtemb.2014.11.007",

language = "English",

volume = "30",

pages = "107--111",

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T1 - Performance IQ in children is associated with blood cadmium concentration in early pregnancy

AU - Jeong, Kyoung Sook

AU - Park, Hyewon

AU - Ha, Eunhee

AU - Hong, Yun Chul

AU - Ha, Mina

AU - Park, Hyesook

AU - Kim, Bung Nyun

AU - Lee, Bo Eun

AU - Lee, Soo Jeong

AU - Lee, Kyung Yeon

AU - Kim, Ja Hyeong

AU - Kim, Yangho

N1 - Funding Information: This study was supported by MOCEH (Mothers and Children's Environmental Health) project funded by the National Institute of Environmental Research , Republic of Korea. Publisher Copyright: © 2014 Elsevier GmbH.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Method: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Results: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Conclusion: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.

AB - Objective: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Method: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Results: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Conclusion: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.

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KW - Performance

KW - WPPSI-R

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ER -

Performance IQ in children is associated with blood cadmium concentration in early pregnancy

Abstract

Bibliographical note

Keywords

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