Performance IQ in children is associated with blood cadmium concentration in early pregnancy

Kyoung Sook Jeong, Hyewon Park, Eunhee Ha, Yun Chul Hong, Mina Ha, Hyesook Park, Bung Nyun Kim, Bo Eun Lee, Soo Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Yangho Kim

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Objective: To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Method: The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Results: Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Conclusion: Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Trace Elements in Medicine and Biology
Volume30
DOIs
StatePublished - 1 Apr 2015

Bibliographical note

Funding Information:
This study was supported by MOCEH (Mothers and Children's Environmental Health) project funded by the National Institute of Environmental Research , Republic of Korea.

Publisher Copyright:
© 2014 Elsevier GmbH.

Keywords

  • Blood cadmium
  • IQ
  • Performance
  • WPPSI-R

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