Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures

Chan Jin Kim, Ji eun Park, Xiaole Hu, Shine K. Albert, So Jung Park

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.

Original languageEnglish
Pages (from-to)2276-2284
Number of pages9
JournalACS Nano
Volume14
Issue number2
DOIs
StatePublished - 25 Feb 2020

Keywords

  • DNA
  • block copolymer
  • nanofiber
  • nanosheet
  • peptide
  • self-assembly

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