Abstract
We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.
Original language | English |
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Pages (from-to) | 2276-2284 |
Number of pages | 9 |
Journal | ACS Nano |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - 25 Feb 2020 |
Bibliographical note
Publisher Copyright:© 2020 American Chemical Society.
Keywords
- DNA
- block copolymer
- nanofiber
- nanosheet
- peptide
- self-assembly