Abstract
Aim: The aim of the study was to estimate the prevalence of pelvic insufficiency fractures (PIFs) after radiation therapy (RT) in patients with cervical cancer. Patients and Methods: A total of 3,633 patients from 15 cohort studies were included. Proportion meta-analysis was performed to estimate prevalence and subgroup analysis was performed according to imaging modalities for diagnosis of PIF. For continuous variables (age and length of follow-up), meta-regression analysis was performed. Results: Pooled prevalence estimate of PIF was 14% (95% CI=10-19). Incidence of PIF was higher in studies that used MRI as a diagnostic tool (17%, 95% CI=12-22) than non-MRI (8%, 95% CI=2-14). In meta-regression, we found a significant association of prevalence of PIF with age (p=0.021) but not with length of follow-up (p=0.118). Conclusion: PIF after RT in patients with cervical cancer is not rare. Physicians need to pay attention to PIFs, especially in patients with high-risk factors for osteoporotic fracture.
| Original language | English |
|---|---|
| Pages (from-to) | 1109-1115 |
| Number of pages | 7 |
| Journal | In Vivo |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2021 |
Bibliographical note
Funding Information:This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0284).
Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.
Keywords
- Cervical cancer
- Insufficiency fracture
- Osteoporosis
- Survivoral care