Pelvic insufficiency fractures in cervical cancer after radiation therapy: A meta-analysis and review

Youn Kyung Chung, Young Kyun Lee, Byung Ho Yoon, Dong Hoon Suh, Kyung Hoi Koo

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13 Scopus citations


Aim: The aim of the study was to estimate the prevalence of pelvic insufficiency fractures (PIFs) after radiation therapy (RT) in patients with cervical cancer. Patients and Methods: A total of 3,633 patients from 15 cohort studies were included. Proportion meta-analysis was performed to estimate prevalence and subgroup analysis was performed according to imaging modalities for diagnosis of PIF. For continuous variables (age and length of follow-up), meta-regression analysis was performed. Results: Pooled prevalence estimate of PIF was 14% (95% CI=10-19). Incidence of PIF was higher in studies that used MRI as a diagnostic tool (17%, 95% CI=12-22) than non-MRI (8%, 95% CI=2-14). In meta-regression, we found a significant association of prevalence of PIF with age (p=0.021) but not with length of follow-up (p=0.118). Conclusion: PIF after RT in patients with cervical cancer is not rare. Physicians need to pay attention to PIFs, especially in patients with high-risk factors for osteoporotic fracture.

Original languageEnglish
Pages (from-to)1109-1115
Number of pages7
JournalIn Vivo
Issue number2
StatePublished - Mar 2021

Bibliographical note

Funding Information:
This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0284).

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.


  • Cervical cancer
  • Insufficiency fracture
  • Osteoporosis
  • Survivoral care


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