@article{3e5aa5b86fbd48799073a43a518d03d6,
title = "Pd-Catalyzed Aminocarbonylation of the Blaise Reaction Intermediate: One-Pot Synthesis of (Z)-3-Methyleneisoindolin-1-ones from Nitriles",
abstract = "A highly efficient method for the one-pot synthesis of stereocontrolled (Z)-3-methyleneisoindolin-1-ones was developed starting from 2-bromoarylnitriles via tandem sequential reaction with a Reformatsky reagent (Blaise reaction), followed by Pd-catalyzed intramolecular aminocarbonylation with carbon monoxide at 1 atm pressure. It has been found that the conformational flexibility of the bisphophine ligand is of great importance to the success of this tandem aminocarbonylation reaction.",
author = "Zi Xuan and Jung, {Da Jung} and Jeon, {Hyun Ji} and Lee, {Sang Gi}",
note = "Funding Information: The authors acknowledge the financial support of this work from the National Research Foundation of Korea (NRF-2016R1A2B2013727). We thank Dr. Y. Kim at NanoBio Institute in Ewha Womans University for X-ray analysis. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = oct,
day = "21",
doi = "10.1021/acs.joc.6b02095",
language = "English",
volume = "81",
pages = "10094--10098",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "20",
}