Pattern of polymorphism after strong artificial selection in a domestication event

Hideki Innan, Yuseob Kim

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

The process of strong artificial selection during a domestication event is modeled, and its effect on the pattern of DNA polymorphism is investigated. The model also considers population bottleneck during domestication. Artificial selection during domestication is different from a regular selective sweep because artificial selection acts on alleles that may have been neutral variants before domestication. Therefore, the fixation of such a beneficial allele does not always wipe out DNA variation in the surrounding region. The amount by which variation is reduced largely depends on the initial frequency of the beneficial allele, p. Asa consequence, p has a strong effect on the likelihood of detecting the signature of selection during domestication from patterns of polymorphism. These theoretical results are discussed in light of data collected from maize. Although the main focus of this article is on domestication, this model can also be generalized to describe selective sweeps from standing genetic variation.

Original languageEnglish
Pages (from-to)10667-10672
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number29
DOIs
StatePublished - 20 Jul 2004

Keywords

  • Coalescent
  • Domestication selection
  • Population genetics
  • Theory

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