Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase

So Young Hong, Ji Yeon Kim, Hee Yoon Ahn, Jae Ho Shin, Oran Kwon

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37 Scopus citations

Abstract

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a fundamental regulator of systemic blood pressure. Ginsenosides from Panax ginseng have been investigated in vitro for the molecular and biochemical mechanisms by which they stimulate NO release in vascular endothelial cells; however, little research has been done to confirm the physiological relevance of these in vitro studies. To address this research gap, the effects of a P. ginseng extract rich in ginsenosides from protopanaxatriol on spontaneously hypertensive rats (SHRs) was examined. Ginseng extract administration stimulated nongenomic Akt-mediated eNOS activation, enhanced NO production, improved vessel wall thickening, and alleviated hypertension in SHRs, confirming the physiological relevance of previous in vitro studies with ginsenosides.

Original languageEnglish
Pages (from-to)3086-3091
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number12
DOIs
StatePublished - 28 Mar 2012

Keywords

  • endothelial nitric oxide synthase
  • ginsenoside
  • nitric oxide
  • spontaneously hypertensive rats

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