Palladium Probe Consisting of Naphthalimide and Ethylenediamine for Selective Turn-On Sensing of CO and Cell Imaging

Anjong Florence Tikum, Wanyoung Lim, Maxine Mambo Fortibui, Sohyun Lee, Sungsu Park, Jinheung Kim

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8 Scopus citations


An assay to detect carbon monoxide (CO), one of the gaseous signaling molecules, has been prepared using a new palladium complex probe. The ethylenediamine group linked to the naphthalimide fluorophore coordinates to Pd(II) which intramolecularly quenches the emission. Upon treatment with CO, the absorbance of the turn-on fluorescent sensor changes due to the formation of a complex between Pd(II) and CO at room temperature in a phosphate buffer. As the concentration of CO increases, the probe peak emission intensity at 527 nm gradually increases. Other analyte controls, such as K+, Mg2+, Al3+, Zn2+, Cr3+, Hg2+, Fe3+, alanine, glycine, leucine, lysine, serine, threonine, tyrosine, F-, Cl-, Br-, NO, NO2-, NO3-, HCO3-, CH3COO-, H2O2, •OH, and tBuOO•, exhibit no significant effect on emission intensity. The response time of the probe to CO was quite fast because of the relatively weak coordination of Pd(II) to the pendent ethylenediamine group. The Pd probe is capable of detecting CO in aqueous buffer as well as in living cells with high selectivity and stability, providing a potential real-time indicator for studying CO-involved reactions in biological systems.

Original languageEnglish
Pages (from-to)7108-7114
Number of pages7
JournalInorganic Chemistry
Issue number10
StatePublished - 17 May 2021

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) grant funded by the Korean government (NRF-2017R1A5A1015365) and the “Next Generation Carbon Upcycling Project” (project no. 2017M1A2A2046740) and Future Planning (NRF-2016M3A9B4917320 to S.P.) through NRF funded by the Ministry of Science and ICT.

Publisher Copyright:
© 2021 American Chemical Society.


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