Palladium-catalyzed peripheral arylation of 5-pyrazolones via enolizable bond protection

Hye Rin Bin, Yun Soo Bae, Guncheol Kim, Kee In Lee

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Peripheral cross-coupling of the enol form of the 5-pyrazolone scaffold with arylboronic acids promoted by [PdCldppf)] afforded the arylated products in good yields. In this coupling, the protection of the enolizable hydroxyl group of pyrazolone is a prerequisite for ensuring the Suzuki-Miyaura cross-coupling. A particular feature of this process is that it enables the synthesis of 5-hydroxy-3-biphenyl and -terphenylpyrazole derivatives with structural diversity.

Original languageEnglish
Pages (from-to)1783-1791
Number of pages9
JournalSynthesis (Germany)
Issue number11
StatePublished - 2011


  • arylpyrazole
  • peripheral arylation
  • pyrazolone
  • Suzuki-Miyaura
  • tautomers


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