@article{742b0fc2d40d4d04ad749325e4955b06,
title = "Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)−H Bond Activation",
abstract = "Reported is a tandem palladium-catalyzed Heck/regioselective C(sp3)−H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C−H bond activation in the σ-alkylPdII intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent molecules could influence the transition-state energy, leading to a bifurcation of the C−H bond activation in the σ-alkylPdII intermediate.",
keywords = "C−H activation, heterocylces, palladium, reaction mechanisms, solvent effects",
author = "Chung, {Da Sol} and Lee, {Jae Sung} and Ho Ryu and Jiyong Park and Hyunjoong Kim and Lee, {Joo Hyun} and Kim, {U. Bin} and Lee, {Won Koo} and Baik, {Mu Hyun} and Lee, {Sang gi}",
note = "Funding Information: This work was made possible by the support of the National Research Foundation (NRF-2016R1A2B2013727). D.S.C. acknowledges the Solvay Fellowship. We thank Dr. Y. Kim for X-ray analysis. We also thank Prof. S. Chang at KAIST for use of the time-resolved infrared spectrometer. M.-H.B. acknowledges the financial support from the Institute for Basic Science (IBS-R10-D1). Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = nov,
day = "19",
doi = "10.1002/anie.201809133",
language = "English",
volume = "57",
pages = "15460--15464",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "47",
}