P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells

Hyang Rim Kim; Soo Yeon Chung; Yeon Hee Jeong; Eun Jung Go; Ah Reum Han; Na Hyung Kim; Min KyungSung; Gina Song; Jung Ok Jang; Joo Won Nam; Hwa Jeong Lee; Eun Kyoung Seo

P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells

Hyang Rim Kim, Soo Yeon Chung, Yeon Hee Jeong, Eun Jung Go, Ah Reum Han, Na Hyung Kim, Min KyungSung, Gina Song, Jung Ok Jang, Joo Won Nam, Hwa Jeong Lee, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC₅₀ values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC₅₀ values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Natural Product Sciences
Volume	10
Issue number	6
State	Published - Dec 2004

Keywords

Daunomycin
Indonesian plants
MCF-7/ADR cell
P-glycoprotem

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title = "P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells",

abstract = "In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC50 values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.",

keywords = "Daunomycin, Indonesian plants, MCF-7/ADR cell, P-glycoprotem",

author = "Kim, {Hyang Rim} and Chung, {Soo Yeon} and Jeong, {Yeon Hee} and Go, {Eun Jung} and Han, {Ah Reum} and Kim, {Na Hyung} and Min KyungSung and Gina Song and Jang, {Jung Ok} and Nam, {Joo Won} and Lee, {Hwa Jeong} and Seo, {Eun Kyoung}",

year = "2004",

month = dec,

language = "English",

volume = "10",

pages = "268--271",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

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TY - JOUR

T1 - P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells

AU - Kim, Hyang Rim

AU - Chung, Soo Yeon

AU - Jeong, Yeon Hee

AU - Go, Eun Jung

AU - Han, Ah Reum

AU - Kim, Na Hyung

AU - KyungSung, Min

AU - Song, Gina

AU - Jang, Jung Ok

AU - Nam, Joo Won

AU - Lee, Hwa Jeong

AU - Seo, Eun Kyoung

PY - 2004/12

Y1 - 2004/12

N2 - In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC50 values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

AB - In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC50 values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

KW - Daunomycin

KW - Indonesian plants

KW - MCF-7/ADR cell

KW - P-glycoprotem

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M3 - Article

AN - SCOPUS:20044382587

SN - 1226-3907

VL - 10

SP - 268

EP - 271

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 6

ER -

P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells

Abstract

Keywords

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