P-glycoprotein inhibitory activity of Indonesian medicinal plants in human breast cancer cells

Hyang Rim Kim, Soo Yeon Chung, Yeon Hee Jeong, Eun Jung Go, Ah Reum Han, Na Hyung Kim, Min KyungSung, Gina Song, Jung Ok Jang, Joo Won Nam, Hwa Jeong Lee, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC50 values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

Original languageEnglish
Pages (from-to)268-271
Number of pages4
JournalNatural Product Sciences
Volume10
Issue number6
StatePublished - Dec 2004

Keywords

  • Daunomycin
  • Indonesian plants
  • MCF-7/ADR cell
  • P-glycoprotem

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