Oyster-derived tyr-ala (Ya) peptide prevents lipopolysaccharide/d-galactosamine-induced acute liver failure by suppressing inflammatory, apoptotic, ferroptotic, and pyroptotic signals

Adrian S. Siregar, Marie Merci Nyiramana, Eun Jin Kim, Soo Buem Cho, Min Seok Woo, Dong Kun Lee, Seong Geun Hong, Jaehee Han, Sang Soo Kang, Deok Ryong Kim, Yeung Joon Choi, Dawon Kang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Models created by the intraperitoneal injection of lipopolysaccharide (LPS) and D-galactosamine (D-GalN) have been widely used to study the pathogenesis of human acute liver failure (ALF) and drug development. Our previous study reported that oyster (Crassostrea gigas) hydrolysate (OH) had a hepatoprotective effect in LPS/D-GalN-injected mice. This study was performed to iden-tify the hepatoprotective effect of the tyrosine-alanine (YA) peptide, the main component of OH, in a LPS/D-GalN-injected ALF mice model. We analyzed the effect of YA on previously known mechanisms of hepatocellular injury in the model. LPS/D-GalN-injected mice showed inflamma-tory, apoptotic, ferroptotic, and pyroptotic liver injury. The pre-administration of YA (10 mg/kg or 50 mg/kg) significantly reduced the liver damage factors. The hepatoprotective effect of YA was higher in the 50 mg/kg YA pre-administered group than in the 10 mg/kg YA pre-administered group. These results showed that YA had a hepatoprotective effect by reducing inflammation, apoptosis, ferroptosis, and pyroptosis in the LPS/D-GalN-injected ALF mouse model. We suggest that YA can be used as a functional peptide for the prevention of acute liver injury.

Original languageEnglish
Article number614
JournalMarine Drugs
Volume19
Issue number11
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation of Korea (MSIT, NRF-2015R1A-5A-2008833 and 2021R1I1A3044128) and by the Ministry of Oceans and Fisheries (Korea, D11410119H480000110/#2014042).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Acute liver injury
  • Apoptosis
  • Ferroptosis
  • Inflammation
  • Oyster
  • Peptide
  • Pyroptosis

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