Oxytocin receptor gene (OXTR) is related to psychological resources

Shimon Saphire-Bernstein; Baldwin M. Way; Heejung S. Kim; David K. Sherman; Shelley E. Taylor

doi:10.1073/pnas.1113137108

Oxytocin receptor gene (OXTR) is related to psychological resources

Shimon Saphire-Bernstein
, Baldwin M. Way
, Heejung S. Kim
, David K. Sherman
, Shelley E. Taylor

Department of Psychology

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

Psychological resources-optimism, mastery, and self-esteem-bufferthe deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largelymediated by the influence of OXTRon psychological resources.

Original language	English
Pages (from-to)	15118-15122
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	108
Issue number	37
DOIs	https://doi.org/10.1073/pnas.1113137108
State	Published - 13 Sep 2011

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AU - Saphire-Bernstein, Shimon

AU - Way, Baldwin M.

AU - Kim, Heejung S.

AU - Sherman, David K.

AU - Taylor, Shelley E.

PY - 2011/9/13

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N2 - Psychological resources-optimism, mastery, and self-esteem-bufferthe deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largelymediated by the influence of OXTRon psychological resources.

AB - Psychological resources-optimism, mastery, and self-esteem-bufferthe deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largelymediated by the influence of OXTRon psychological resources.

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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Oxytocin receptor gene (OXTR) is related to psychological resources

Abstract

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