TY - JOUR
T1 - Oxytocin receptor gene (OXTR) is related to psychological resources
AU - Saphire-Bernstein, Shimon
AU - Way, Baldwin M.
AU - Kim, Heejung S.
AU - Sherman, David K.
AU - Taylor, Shelley E.
PY - 2011/9/13
Y1 - 2011/9/13
N2 - Psychological resources-optimism, mastery, and self-esteem-bufferthe deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largelymediated by the influence of OXTRon psychological resources.
AB - Psychological resources-optimism, mastery, and self-esteem-bufferthe deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largelymediated by the influence of OXTRon psychological resources.
UR - http://www.scopus.com/inward/record.url?scp=80053070030&partnerID=8YFLogxK
U2 - 10.1073/pnas.1113137108
DO - 10.1073/pnas.1113137108
M3 - Article
C2 - 21896752
AN - SCOPUS:80053070030
SN - 0027-8424
VL - 108
SP - 15118
EP - 15122
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 37
ER -