Oxidizing intermediates in cytochrome P450 model reactions

Wonwoo Nam, Yon Ok Ryu, Woon Ju Song

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Oxoiron(IV) porphyrin π-cation radicals have been considered as the sole reactive species in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin models over the past two decades. Recent studies from several laboratories, however, have provided experimental evidence that multiple oxidizing species are involved in the oxygen transfer reactions and that the mechanism of oxygen transfer is much more complex than initially believed. In this Commentary, reactive intermediates that have been shown or proposed to be involved in iron porphyrin complex-catalyzed oxidation reactions are reviewed. Particularly, the current controversy on the oxoiron(IV) porphyrin π-cation radical as a sole reactive species versus the involvement of multiple oxidizing species in oxygen transfer reactions is discussed.

Original languageEnglish
Pages (from-to)654-660
Number of pages7
JournalJournal of Biological Inorganic Chemistry
Issue number6
StatePublished - Sep 2004

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the Ministry of Science and Technology of Korea through the Creative Research Initiative Program and the Korea Science and Engineering Foundation (R02-2003-000-10047-0).


  • Compound I
  • Cytochrome P450
  • Iron porphyrin
  • Multiple oxidants
  • Oxidation


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