Oxidative stress sensing and response in neural stem cell fate

Inah Hwang, Deanna Tang, Jihye Paik

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the adult brain and make up its regenerative potential. It is thus essential to understand how different factors influence their proliferation and differentiation to gain better insight into potential therapeutic targets in neurodegenerative diseases and traumatic brain injuries. Recent evidences indicate the roles of redox stress sensing and coping mechanisms in mediating the balance between NSPC self-renewal and differentiation. Such mechanisms involve direct cysteine modification, signaling and metabolic reprogramming, epigenetic alterations and transcription changes leading to adaptive responses like autophagy. Here, we discuss emerging findings on the involvement of redox sensors and effectors and their mechanisms in influencing changes in cellular redox potential and NSPC fate.

Original languageEnglish
Pages (from-to)74-83
Number of pages10
JournalFree Radical Biology and Medicine
Volume169
DOIs
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

  • Cell fate
  • Cysteine sulfenylation
  • Neural stem cells
  • Oxidative stress
  • Reactive oxygen species
  • Redox signaling

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