Oxidative stress-related gene polymorphism and the risk of preeclampsia

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Abstract

Objective: The purpose of this study was to determine whether genetic variability in oxidative stress-related enzymes contributes to individual preeclampsia susceptibility differences. Study Design: Polymorphisms in the cytochrome P450 (CYP)1A1 (MspI), CYP1A1(Ile/Val), glutathione S-transferase (GST)M1, GSTT1, myeloperoxidase (MPO), and manganese superoxide dismutase (MnSOD) genes were evaluated by polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP) in 214 healthy controls with an uncomplicated obstetric history, and in 121 preeclampsia patients. χ 2 analyses were used to statistically evaluate differences. Results: No significant differences in the CYP1A1(MspI) or CYP1A1(Ile/Val) genotypes were observed between the healthy controls and the preeclampsia patients (χ 2 = 1.43, P = 0.49 versus χ 2 = 1.54, P = 0.46). The GSTM1 homozygous null type and GSTT1 homozygous null type were no differences in the patients and controls (χ 2 = 0.01, P = 0.92 versus χ 2 = 0.31, P = 0.57), and no significant differences in the polymorphisms of the MPO and MnSOD genotypes were found between the patients and controls (χ 2 = 2.00, P = 0.37 versus χ 2 = 0.07, P = 0.96). Conclusion: Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume119
Issue number1
DOIs
StatePublished - 1 Mar 2005

Bibliographical note

Funding Information:
This work was supported by grant no.(R01-2003-000-10466-0) from the Korean Science & Engineering Foundation and grant no.(03-PJ1-PG10-21900-0001) from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.

Keywords

  • CYP1A1 genotype
  • GSTT genotype
  • MnSOD genotype
  • MPO genotype
  • Preeclampsia
  • Stress-related enzyme

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