TY - JOUR
T1 - Oxidative stress-related gene polymorphism and the risk of preeclampsia
AU - Kim, Young Ju
AU - Park, Hye Sook
AU - Park, Mi Hye
AU - Suh, Suk Hyo
AU - Pang, Myung Geol
N1 - Funding Information:
This work was supported by grant no.(R01-2003-000-10466-0) from the Korean Science & Engineering Foundation and grant no.(03-PJ1-PG10-21900-0001) from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Objective: The purpose of this study was to determine whether genetic variability in oxidative stress-related enzymes contributes to individual preeclampsia susceptibility differences. Study Design: Polymorphisms in the cytochrome P450 (CYP)1A1 (MspI), CYP1A1(Ile/Val), glutathione S-transferase (GST)M1, GSTT1, myeloperoxidase (MPO), and manganese superoxide dismutase (MnSOD) genes were evaluated by polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP) in 214 healthy controls with an uncomplicated obstetric history, and in 121 preeclampsia patients. χ 2 analyses were used to statistically evaluate differences. Results: No significant differences in the CYP1A1(MspI) or CYP1A1(Ile/Val) genotypes were observed between the healthy controls and the preeclampsia patients (χ 2 = 1.43, P = 0.49 versus χ 2 = 1.54, P = 0.46). The GSTM1 homozygous null type and GSTT1 homozygous null type were no differences in the patients and controls (χ 2 = 0.01, P = 0.92 versus χ 2 = 0.31, P = 0.57), and no significant differences in the polymorphisms of the MPO and MnSOD genotypes were found between the patients and controls (χ 2 = 2.00, P = 0.37 versus χ 2 = 0.07, P = 0.96). Conclusion: Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia.
AB - Objective: The purpose of this study was to determine whether genetic variability in oxidative stress-related enzymes contributes to individual preeclampsia susceptibility differences. Study Design: Polymorphisms in the cytochrome P450 (CYP)1A1 (MspI), CYP1A1(Ile/Val), glutathione S-transferase (GST)M1, GSTT1, myeloperoxidase (MPO), and manganese superoxide dismutase (MnSOD) genes were evaluated by polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP) in 214 healthy controls with an uncomplicated obstetric history, and in 121 preeclampsia patients. χ 2 analyses were used to statistically evaluate differences. Results: No significant differences in the CYP1A1(MspI) or CYP1A1(Ile/Val) genotypes were observed between the healthy controls and the preeclampsia patients (χ 2 = 1.43, P = 0.49 versus χ 2 = 1.54, P = 0.46). The GSTM1 homozygous null type and GSTT1 homozygous null type were no differences in the patients and controls (χ 2 = 0.01, P = 0.92 versus χ 2 = 0.31, P = 0.57), and no significant differences in the polymorphisms of the MPO and MnSOD genotypes were found between the patients and controls (χ 2 = 2.00, P = 0.37 versus χ 2 = 0.07, P = 0.96). Conclusion: Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia.
KW - CYP1A1 genotype
KW - GSTT genotype
KW - MnSOD genotype
KW - MPO genotype
KW - Preeclampsia
KW - Stress-related enzyme
UR - http://www.scopus.com/inward/record.url?scp=14244266433&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2004.06.009
DO - 10.1016/j.ejogrb.2004.06.009
M3 - Article
C2 - 15734083
AN - SCOPUS:14244266433
SN - 0301-2115
VL - 119
SP - 42
EP - 46
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
IS - 1
ER -