Overview of Structural Genomics: Landscape, Premises, and Current Direction

Sung Hou Kim, Dong Hae Shin, Weiru Wang, Paul D. Adams, John Marc Chandonia

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Analyses of human genome yield an estimate of about 20,000 genes [Venter et al. 2001, Lander et al. 2001, and subsequent estimates] in Homo sapiens, which is only about 40 times greater than the smallest sequenced genome, Mycoplasma genitalium , encoding ~470 genes. In higher organisms the number of proteins, however, may be an order of magnitude more than the number of genes due to alternative splicing, posttranslational modification and processing, etc. When this multiplicity is taken into account, the protein universe is even more vast and diverse.

Original languageEnglish
Title of host publicationStructural Genomics and High Throughput Structural Biology
PublisherCRC Press
Number of pages18
ISBN (Electronic)9780849361432
ISBN (Print)9780824753351
StatePublished - 1 Jan 2005

Bibliographical note

Publisher Copyright:
© 2006 by Taylor and Francis Group, LLC.


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