Outcome of Regular Inhaled Treatment in GOLD A Chronic Obstructive Pulmonary Disease Patients

Jaeyoung Cho, Chang Hoon Lee, Yong Il Hwang, Jin Hwa Lee, Tae Hyung Kim, Ji Hyun Lee, Yeon Mok Oh, Kwang Ha Yoo, Ki Suck Jung, Sang Do Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: The 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends regular bronchodilator therapy in all group A patients with chronic obstructive pulmonary disease (COPD). Objective: The aim of this study was to evaluate whether regular inhaled treatment in group A patients with COPD improves their health outcomes, including exacerbations and symptoms. Methods: We recruited patients from 2 Korean prospective cohorts. Eligible COPD patients had a modified Medical Research Council (mMRC) dyspnea score of <2, a St. George's Respiratory Questionnaire for COPD (SGRQ-C) total score of <25, and had no more than 1 exacerbation and no hospitalizations during the previous year. Incidence rates of exacerbations and changes in symptom scores were analyzed. Results: After propensity score matching, there were 107 patient pairs, with and without regular inhaled treatment, who were followed up for mean times of 2.6 and 3.1 years, respectively. The incidence rates of exacerbations in those with and without regular treatment were not significantly different (incidence rate ratio 1.24 [95% CI 0.68 to 2.25]). Significant differences in favor of regular treatment were observed at 6 and 12 months for the SGRQ-C total scores (mean between-group difference-4.7 [95% CI-7.9 to-1.6] and-4.8 [95% CI-7.9 to-1.7], respectively). Regular treatment with a long-acting bronchodilator was also associated with significantly better scores on the SGRQ-C (mean between-group difference-5.0 [95% CI-8.6 to-1.4]) compared to no regular treatment at 12 months of follow-up. Conclusions: Regular inhaled treatment in group A patients with COPD was associated with a symptomatic benefit but not with a reduction of exacerbation rates.

Original languageEnglish
Pages (from-to)312-320
Number of pages9
Issue number4
StatePublished - 1 Oct 2019

Bibliographical note

Funding Information:
This study included participants from 2 Korean cohorts, KOLD and KOCOSS. KOLD was built with the support of a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (A102065).

Publisher Copyright:
© 2019 S. Karger AG, Basel. All rights reserved.


  • Acute exacerbation
  • Chronic obstructive pulmonary disease
  • Group A
  • Inhaled therapy


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