Outcome analysis of chemoradiation in unresectable pancreatic cancer focusing on treatment sequencing strategy

Hyeon Kang Koh, Eui Kyu Chie, Kyubo Kim, Jin Young Jang, Sun Whe Kim, Do Youn Oh, Seock Ah Im, Yung Jue Bang, Sung W. Ha

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To analyze the outcomes of patients with unresectable pancreatic cancer after chemoradiotherapy (CCRT), focusing on sequencing strategy. Patients and Methods: Data of 144 patients treated from January 1989 to December 2013 were retrospectively analyzed. Patients were divided into the scheduled group (N=27), salvage group (N=37) and upfront group (N=80) per CCRT and chemotherapy sequence. Results: With a median follow-up of 10.4 months (range=1.4-164.2), median overall survival (OS) was 13.5 months. Patients in the upfront group had inferior performance status and received a lower radiation dose (p=0.007 and p<0.001, respectively). Higher radiation dose (45 Gy) was the sole prognosticator related with improved survival in multivariate (p=0.001) analysis, whereas treatment sequence was not a significant prognostic factor (p=0.409). Conclusion: No difference was found among tested sequencing strategies that were all welltolerated, despite skewed distribution for performance and radiation dose. An upfront approach may be a viable option for patients with limited performance to undergo more active systemic chemotherapy.

Original languageEnglish
Pages (from-to)5455-5461
Number of pages7
JournalAnticancer Research
Volume36
Issue number10
DOIs
StatePublished - Oct 2016

Keywords

  • Chemoradiotherapy
  • Chemotherapy
  • Pancreatic cancer
  • Radiation dose

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