Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

H. Lee; E. S. Kim; C. Choi; H. Seo; M. Shin; J. H. Bok; J. E. Cho; C. J. Kim; J. W. Shin; T. S. Kim; K. H. Song; K. U. Park; B. I. Kim; H. B. Kim

doi:10.1016/j.jhin.2014.04.003

Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

H. Lee, E. S. Kim, C. Choi, H. Seo, M. Shin, J. H. Bok, J. E. Cho, C. J. Kim, J. W. Shin, T. S. Kim, K. H. Song, K. U. Park, B. I. Kim, H. B. Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim: To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods: The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings: An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Sixneonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton-Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC. mec) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion: This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.

Original language	English
Pages (from-to)	145-151
Number of pages	7
Journal	Journal of Hospital Infection
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/j.jhin.2014.04.003
State	Published - Jul 2014

Keywords

Community-associated infection
Disease outbreak
Meticillin-resistant Staphylococcus aureus
Newborn
Panton-Valentine leucocidin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jhin.2014.04.003

Cite this

Lee, H., Kim, E. S., Choi, C., Seo, H., Shin, M., Bok, J. H., Cho, J. E., Kim, C. J., Shin, J. W., Kim, T. S., Song, K. H., Park, K. U., Kim, B. I., & Kim, H. B. (2014). Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus. Journal of Hospital Infection, 87(3), 145-151. https://doi.org/10.1016/j.jhin.2014.04.003

@article{f091642729d54d8c9764c9814528bf29,

title = "Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus",

abstract = "Background: The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim: To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods: The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings: An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Sixneonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton-Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC. mec) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion: This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.",

keywords = "Community-associated infection, Disease outbreak, Meticillin-resistant Staphylococcus aureus, Newborn, Panton-Valentine leucocidin",

author = "H. Lee and Kim, {E. S.} and C. Choi and H. Seo and M. Shin and Bok, {J. H.} and Cho, {J. E.} and Kim, {C. J.} and Shin, {J. W.} and Kim, {T. S.} and Song, {K. H.} and Park, {K. U.} and Kim, {B. I.} and Kim, {H. B.}",

year = "2014",

month = jul,

doi = "10.1016/j.jhin.2014.04.003",

language = "English",

volume = "87",

pages = "145--151",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

AU - Lee, H.

AU - Kim, E. S.

AU - Choi, C.

AU - Seo, H.

AU - Shin, M.

AU - Bok, J. H.

AU - Cho, J. E.

AU - Kim, C. J.

AU - Shin, J. W.

AU - Kim, T. S.

AU - Song, K. H.

AU - Park, K. U.

AU - Kim, B. I.

AU - Kim, H. B.

PY - 2014/7

Y1 - 2014/7

N2 - Background: The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim: To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods: The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings: An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Sixneonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton-Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC. mec) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion: This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.

AB - Background: The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim: To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods: The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings: An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Sixneonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton-Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC. mec) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion: This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.

KW - Community-associated infection

KW - Disease outbreak

KW - Meticillin-resistant Staphylococcus aureus

KW - Newborn

KW - Panton-Valentine leucocidin

UR - http://www.scopus.com/inward/record.url?scp=84903440865&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2014.04.003

DO - 10.1016/j.jhin.2014.04.003

M3 - Article

C2 - 24856113

AN - SCOPUS:84903440865

SN - 0195-6701

VL - 87

SP - 145

EP - 151

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 3

ER -

Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this