Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

H. Lee, E. S. Kim, C. Choi, H. Seo, M. Shin, J. H. Bok, J. E. Cho, C. J. Kim, J. W. Shin, T. S. Kim, K. H. Song, K. U. Park, B. I. Kim, H. B. Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim: To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods: The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings: An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Sixneonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton-Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC. mec) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion: This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalJournal of Hospital Infection
Volume87
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Community-associated infection
  • Disease outbreak
  • Meticillin-resistant Staphylococcus aureus
  • Newborn
  • Panton-Valentine leucocidin

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