Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21

Sik Won Choi, Hye Kyoung Shin, Hsin Fang Yang-Yen, Myeung Su Lee, Chang Hoon Lee, Sang Joon Park, Kwang Jin Kim, Kyunglim Lee, Seong Hwan Kim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells.

Original languageEnglish
Pages (from-to)4026-4031
Number of pages6
JournalFEBS Letters
Volume588
Issue number21
DOIs
StatePublished - 3 Nov 2014

Keywords

  • Bone
  • Osteoclast
  • Proliferation
  • TCTP p21

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