Abstract
Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells.
Original language | English |
---|---|
Pages (from-to) | 4026-4031 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 588 |
Issue number | 21 |
DOIs | |
State | Published - 3 Nov 2014 |
Bibliographical note
Publisher Copyright:© 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keywords
- Bone
- Osteoclast
- Proliferation
- TCTP p21