Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Doo Ri Park, Jihee Kim, Gyeong Min Kim, Haeseung Lee, Minhee Kim, Donghyun Hwang, Hana Lee, Han Sung Kim, Wankyu Kim, Min Chan Park, Hyunbo Shim, Soo Young Lee

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58 Scopus citations


Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes controlling OA progression is poor. Here, we report the association of OA with increased levels of osteoclast-associated receptor (OSCAR), an immunoglobulin-like collagen-recognition receptor. In mice, OSCAR deletion abrogates OA manifestations, such as articular cartilage destruction, subchondral bone sclerosis, and hyaline cartilage loss. These effects are a result of decreased chondrocyte apoptosis, which is caused by the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in induced OA. Treatments with human OSCAR-Fc fusion protein attenuates OA pathogenesis caused by experimental OA. Thus, this work highlights the function of OSCAR as a catabolic regulator of OA pathogenesis, indicating that OSCAR blockade is a potential therapy for OA.

Original languageEnglish
Article number4343
JournalNature Communications
Issue number1
StatePublished - 1 Dec 2020

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea funded by the Korea Government (MSIP) (no. 2017M3A9C8030537; no. 2017R1A6A3A11031928; no. 2019R1A5A6099645; and no. 2019R1A6C1010020). We would like to thank Yongwon Choi (University of Pennsylvania, USA) for helpful discussions and suggestions. We thank Jang-Soo Chun (GIST, South Korea) for discussions and help in in vitro studies.

Publisher Copyright:
© 2020, The Author(s).


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