Ortho-TMS benzaldehyde: An effective linchpin for type II anion relay chemistry (ARC)

Amos B. Smith; Won Suk Kim; William M. Wuest

doi:10.1002/anie.200802301

Ortho-TMS benzaldehyde: An effective linchpin for type II anion relay chemistry (ARC)

Amos B. Smith
, Won Suk Kim
, William M. Wuest

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

(Chemical Equation Presented) ARC de triomphe: Ortho-TMS benzaldehyde permits efficient multicomponent union of a variety of nucleophiles and electrophiles, including the first example of a Pd-mediated ARC Type II process. A "proof-of-concept" synthetic sequence was designed and implemented for construction of a focused library of "natural product-like" compounds (see scheme). ARC: anion relay chemistry.

Original language	English
Pages (from-to)	7082-7086
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	37
DOIs	https://doi.org/10.1002/anie.200802301
State	Published - 1 Sep 2008

Keywords

Anion relay chemistry
Cross-coupling
Dithianes
Molecular diversity
Natural products

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AU - Wuest, William M.

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KW - Anion relay chemistry

KW - Cross-coupling

KW - Dithianes

KW - Molecular diversity

KW - Natural products

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ER -

Ortho-TMS benzaldehyde: An effective linchpin for type II anion relay chemistry (ARC)

Abstract

Keywords

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