Ortho-TMS benzaldehyde: An effective linchpin for type II anion relay chemistry (ARC)

Amos B. Smith, Won Suk Kim, William M. Wuest

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

(Chemical Equation Presented) ARC de triomphe: Ortho-TMS benzaldehyde permits efficient multicomponent union of a variety of nucleophiles and electrophiles, including the first example of a Pd-mediated ARC Type II process. A "proof-of-concept" synthetic sequence was designed and implemented for construction of a focused library of "natural product-like" compounds (see scheme). ARC: anion relay chemistry.

Original languageEnglish
Pages (from-to)7082-7086
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number37
DOIs
StatePublished - 1 Sep 2008

Keywords

  • Anion relay chemistry
  • Cross-coupling
  • Dithianes
  • Molecular diversity
  • Natural products

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