TY - JOUR
T1 - Organic photosensitizers for antimicrobial phototherapy
AU - Nguyen, Van Nghia
AU - Zhao, Zheng
AU - Tang, Ben Zhong
AU - Yoon, Juyoung
N1 - Funding Information:
J. Yoon thanks to the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2022R1A2C3005420 and 2021R1A6A1A10039823). B. Z. Tang thanks to the National Science Foundation of China (51620105009), the Innovation and Technology Commission (ITC-CNERC14SC01), and the Science and Technology Plan of Shenzhen (ZDSYS20211021111400001). The authors would like to thank Miss Tran-Thi My Duyen (Chung-Ang University) for helping us to edit the TOC in this manuscript.
Publisher Copyright:
© 2022 The Royal Society of Chemistry
PY - 2022
Y1 - 2022
N2 - Microbial infectious diseases, especially those caused by new and antibiotic-resistant pathogenic microbes, have become a significant threat to global human health. As an antibiotic-free therapy, phototherapy is a promising approach to treat microbial infections due to its spatiotemporal selectivity, non-invasiveness, minimal side effects, and broad antimicrobial spectrum. Although organic photosensitizer-based antimicrobial phototherapy has been extensively studied over the last decade, there has been no specific review article on this topic yet. It is important and timely to summarize recent research progress in this field. This tutorial review highlights the concept and significance of phototherapy and summarizes innovative types of organic photosensitizers with design strategies to deal with microbial infections. In addition, examples of organic antimicrobial photosensitizers, including antibacterial photosensitizers, antiviral photosensitizers, and antifungal photosensitizers are discussed. Finally, current challenges and future directions of organic photosensitizer-based phototherapy for clinical antimicrobial applications are presented. We believe that this tutorial review will provide general guidance for the future development of efficient photosensitizers and encourage preclinical and clinical studies for phototherapy-mediated antimicrobial treatments.
AB - Microbial infectious diseases, especially those caused by new and antibiotic-resistant pathogenic microbes, have become a significant threat to global human health. As an antibiotic-free therapy, phototherapy is a promising approach to treat microbial infections due to its spatiotemporal selectivity, non-invasiveness, minimal side effects, and broad antimicrobial spectrum. Although organic photosensitizer-based antimicrobial phototherapy has been extensively studied over the last decade, there has been no specific review article on this topic yet. It is important and timely to summarize recent research progress in this field. This tutorial review highlights the concept and significance of phototherapy and summarizes innovative types of organic photosensitizers with design strategies to deal with microbial infections. In addition, examples of organic antimicrobial photosensitizers, including antibacterial photosensitizers, antiviral photosensitizers, and antifungal photosensitizers are discussed. Finally, current challenges and future directions of organic photosensitizer-based phototherapy for clinical antimicrobial applications are presented. We believe that this tutorial review will provide general guidance for the future development of efficient photosensitizers and encourage preclinical and clinical studies for phototherapy-mediated antimicrobial treatments.
UR - http://www.scopus.com/inward/record.url?scp=85129201894&partnerID=8YFLogxK
U2 - 10.1039/d1cs00647a
DO - 10.1039/d1cs00647a
M3 - Review article
C2 - 35373787
AN - SCOPUS:85129201894
SN - 0306-0012
JO - Chemical Society Reviews
JF - Chemical Society Reviews
ER -