Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Rui Wang; Xingshu Li; Juyoung Yoon

doi:10.1021/acsami.1c02019

Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Rui Wang, Xingshu Li, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

181 Scopus citations

Abstract

Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.

Original language	English
Pages (from-to)	19543-19571
Number of pages	29
Journal	ACS Applied Materials and Interfaces
Volume	13
Issue number	17
DOIs	https://doi.org/10.1021/acsami.1c02019
State	Published - 5 May 2021

Bibliographical note

Funding Information:
J.Y. thanks the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). X.L. thanks the National Natural Science Foundation of China (Grant No. 22078066).

Publisher Copyright:
©

Keywords

organelle-targeted
photodynamic therapy
photosensitizer
precision
subcellular localization

Access to Document

10.1021/acsami.1c02019

Cite this

@article{9bff4adcd58c4db68a082de3a95afa8c,

title = "Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy",

abstract = "Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.",

keywords = "organelle-targeted, photodynamic therapy, photosensitizer, precision, subcellular localization",

author = "Rui Wang and Xingshu Li and Juyoung Yoon",

note = "Funding Information: J.Y. thanks the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). X.L. thanks the National Natural Science Foundation of China (Grant No. 22078066). Publisher Copyright: {\textcopyright} ",

year = "2021",

month = may,

day = "5",

doi = "10.1021/acsami.1c02019",

language = "English",

volume = "13",

pages = "19543--19571",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

AU - Wang, Rui

AU - Li, Xingshu

AU - Yoon, Juyoung

N1 - Funding Information: J.Y. thanks the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). X.L. thanks the National Natural Science Foundation of China (Grant No. 22078066). Publisher Copyright: ©

PY - 2021/5/5

Y1 - 2021/5/5

N2 - Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.

AB - Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.

KW - organelle-targeted

KW - photodynamic therapy

KW - photosensitizer

KW - precision

KW - subcellular localization

UR - http://www.scopus.com/inward/record.url?scp=85106143480&partnerID=8YFLogxK

U2 - 10.1021/acsami.1c02019

DO - 10.1021/acsami.1c02019

M3 - Review article

C2 - 33900741

AN - SCOPUS:85106143480

SN - 1944-8244

VL - 13

SP - 19543

EP - 19571

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this