Abstract
We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe 3 O 4 ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe 3 O 4 ) exhibited the shortest transversal relaxation time, T 2 , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.
Original language | English |
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Pages (from-to) | 205-213 |
Number of pages | 9 |
Journal | Polymer |
Volume | 161 |
DOIs | |
State | Published - 14 Jan 2019 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Ltd
Keywords
- Conjugated polymers
- Hybrid nanoparticles
- Iron oxides
- Magnetic resonance imaging
- Photoacoustic imaging