Ordered assemblies of Fe                         3                         O                         4                          and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects

Thi Thuy Duong Pham; Young Hun Seo; Dabin Lee; Juran Noh; Jeongwan Chae; Eunah Kang; Jae Hong Park; Tae Joo Shin; Sehoon Kim; Juhyun Park

doi:10.1016/j.polymer.2018.12.020

Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects

Thi Thuy Duong Pham, Young Hun Seo, Dabin Lee, Juran Noh, Jeongwan Chae, Eunah Kang, Jae Hong Park, Tae Joo Shin, Sehoon Kim, Juhyun Park

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe ₃ O ₄ ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe ₃ O ₄ ) exhibited the shortest transversal relaxation time, T ₂ , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.

Original language	English
Pages (from-to)	205-213
Number of pages	9
Journal	Polymer
Volume	161
DOIs	https://doi.org/10.1016/j.polymer.2018.12.020
State	Published - 14 Jan 2019

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea grants funded by the Korean government (NRF-2016R1D1A1A02937538, 2017M2A2A6A01021427, and 2017M3A9D8029942) and by JSPS KAKENHI (Grant Number 17H06791). Experiments on the PLS-II 6D beamlines were supported in part by MSIT, POSTECH, and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science (KRISS-2018-GP2018-0018) for KIST intramural program.

Funding Information:
This work was supported by National Research Foundation of Korea grants funded by the Korean government ( NRF-2016R1D1A1A02937538 , 2017M2A2A6A01021427 , and 2017M3A9D8029942 ) and by JSPS KAKENHI (Grant Number 17H06791 ). Experiments on the PLS-II 6D beamlines were supported in part by MSIT , POSTECH , and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science ( KRISS-2018-GP2018-0018 ) for KIST intramural program.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Conjugated polymers
Hybrid nanoparticles
Iron oxides
Magnetic resonance imaging
Photoacoustic imaging

Access to Document

10.1016/j.polymer.2018.12.020

Cite this

Pham, T. T. D., Seo, Y. H., Lee, D., Noh, J., Chae, J., Kang, E., Park, J. H., Shin, T. J., Kim, S., & Park, J. (2019). Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects Polymer, 161, 205-213. https://doi.org/10.1016/j.polymer.2018.12.020

Pham, Thi Thuy Duong ; Seo, Young Hun ; Lee, Dabin et al. / Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects In: Polymer. 2019 ; Vol. 161. pp. 205-213.

@article{97228d6f4e4843aebce6372d2af83825,

title = " Ordered assemblies of Fe 3 O 4 and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects ",

abstract = " We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe 3 O 4 ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe 3 O 4 ) exhibited the shortest transversal relaxation time, T 2 , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties. ",

keywords = "Conjugated polymers, Hybrid nanoparticles, Iron oxides, Magnetic resonance imaging, Photoacoustic imaging",

author = "Pham, {Thi Thuy Duong} and Seo, {Young Hun} and Dabin Lee and Juran Noh and Jeongwan Chae and Eunah Kang and Park, {Jae Hong} and Shin, {Tae Joo} and Sehoon Kim and Juhyun Park",

note = "Funding Information: This work was supported by National Research Foundation of Korea grants funded by the Korean government (NRF-2016R1D1A1A02937538, 2017M2A2A6A01021427, and 2017M3A9D8029942) and by JSPS KAKENHI (Grant Number 17H06791). Experiments on the PLS-II 6D beamlines were supported in part by MSIT, POSTECH, and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science (KRISS-2018-GP2018-0018) for KIST intramural program. Funding Information: This work was supported by National Research Foundation of Korea grants funded by the Korean government ( NRF-2016R1D1A1A02937538 , 2017M2A2A6A01021427 , and 2017M3A9D8029942 ) and by JSPS KAKENHI (Grant Number 17H06791 ). Experiments on the PLS-II 6D beamlines were supported in part by MSIT , POSTECH , and UNIST Central Research Facilities. JP acknowledges Profs. Tsunehiro Tanaka and Kentaro Teramura for access to a UV–vis spectrometer and Dr. Yasunari Tamai and Mr. Yasuhiro Murata for their assistance on fs-TA measurements. SK thanks Korea Research Institute of Standards and Science ( KRISS-2018-GP2018-0018 ) for KIST intramural program. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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doi = "10.1016/j.polymer.2018.12.020",

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Pham, TTD, Seo, YH, Lee, D, Noh, J, Chae, J, Kang, E, Park, JH, Shin, TJ, Kim, S & Park, J 2019, ' Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects ', Polymer, vol. 161, pp. 205-213. https://doi.org/10.1016/j.polymer.2018.12.020

Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects . / Pham, Thi Thuy Duong; Seo, Young Hun; Lee, Dabin et al.
In: Polymer, Vol. 161, 14.01.2019, p. 205-213.

Research output: Contribution to journal › Article › peer-review

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AU - Pham, Thi Thuy Duong

AU - Seo, Young Hun

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AU - Noh, Juran

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PY - 2019/1/14

Y1 - 2019/1/14

N2 - We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe 3 O 4 ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe 3 O 4 ) exhibited the shortest transversal relaxation time, T 2 , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.

AB - We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe 3 O 4 ) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe 3 O 4 ) exhibited the shortest transversal relaxation time, T 2 , and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.

KW - Conjugated polymers

KW - Hybrid nanoparticles

KW - Iron oxides

KW - Magnetic resonance imaging

KW - Photoacoustic imaging

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Pham TTD, Seo YH, Lee D, Noh J, Chae J, Kang E et al. Ordered assemblies of Fe ₃ O ₄ and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects Polymer. 2019 Jan 14;161:205-213. doi: 10.1016/j.polymer.2018.12.020