TY - JOUR
T1 - Oral health and gastrointestinal cancer
T2 - A nationwide cohort study
AU - Lee, Kijeong
AU - Lee, Ji Sung
AU - Kim, Jinkwon
AU - Lee, Huisong
AU - Chang, Yoonkyung
AU - Woo, Ho Geol
AU - Kim, Jin Woo
AU - Song, Tae Jin
N1 - Funding Information:
This research was funded by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (grant number 2018R1D1A1B07040959).
Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Aims: Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. Materials and Methods: This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15–C26. Results: During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (≥3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86–0.96), p <.001, p for trend <.001). Conclusions: Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
AB - Aims: Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. Materials and Methods: This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15–C26. Results: During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (≥3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86–0.96), p <.001, p for trend <.001). Conclusions: Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
KW - gastrointestinal cancer
KW - oral hygiene
KW - periodontal disease
UR - http://www.scopus.com/inward/record.url?scp=85085511926&partnerID=8YFLogxK
U2 - 10.1111/jcpe.13304
DO - 10.1111/jcpe.13304
M3 - Article
C2 - 32385894
AN - SCOPUS:85085511926
SN - 0303-6979
VL - 47
SP - 796
EP - 808
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 7
ER -