Oral health and changes in lipid profile: A nationwide cohort study

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Abstract

Aim: We aimed to investigate the association of periodontitis and oral hygiene indicators with changes in blood lipid parameters in a nationwide, population-based cohort in a longitudinal setting. Materials and methods: We included nationwide health screening program participants who underwent oral health examination in 2009-2010 and follow-up examinations for lipid profile without exposure to lipid-lowering agents. Results: During the 5.19-year median follow-up, 65,078 individuals (mean age at baseline examination: 55.41 ± 7.30 years) underwent 286,218 health examinations. The prevalence of periodontitis was 39%. In the multivariate mixed model analysis, periodontitis and tooth loss were associated with decreased high-density lipoprotein cholesterol levels (β = −0.0066 mmol/L, standard error = 0.0026, p =.013) and increased triglyceride levels (β=0.0307, mmol/L, standard error = 0.0049, p <.001), respectively. Compared with tooth brushing ≤1 time/day, tooth brushing ≥3 times/day was associated with increased high-density lipoprotein cholesterol levels (β = 0.0176 mmol/L, standard error = 0.0052, p =.006) and decreased triglyceride levels (β = −0.0285 mmol/L, standard error = 0.0090, p =.001). Conclusions: Periodontitis and tooth loss may be attenuating factors for blood high-density lipoprotein cholesterol and triglyceride levels, respectively. Frequent tooth brushing may improve dyslipidaemia, particularly blood high-density lipoprotein cholesterol and triglyceride levels. Oral hygiene improvement may reduce the risk of dyslipidaemia.

Original languageEnglish
Pages (from-to)1437-1445
Number of pages9
JournalJournal of Clinical Periodontology
Volume47
Issue number12
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2020R1I1A1A01060447 to JK). This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1D1A1B07040959 to T-JS). The funders had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript. This study used the data set of NHIS-HEALS (NHIS-2018-2-055) created by the National Health Insurance Sharing Service.

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2020R1I1A1A01060447 to JK). This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1D1A1B07040959 to T‐JS). The funders had no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

  • dyslipidaemia
  • oral hygiene
  • periodontal diseases
  • toothbrushing
  • triglyceride

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