Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model

VAN NAM TRAN, PERIASWAMY SIVAGNANAM SARAVANA, SUHYUN PARK, VAN GIA TRUONG, BYUNG SOO CHUN, HYUN WOOK KANG

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Medical societies and public health agencies rigorously emphasize the importance of adequate disinfection of flexible endoscopes. The aim of this work was to propose a novel opto-chemical disinfection treatment against Staphylococcus aureus grown in mature biofilm on Teflon-based endoscope channel models. Laser irradiation using near-infrared and blue wavelengths combined with a low concentration of chemical disinfectant induced both irreversible thermal denaturation and intercellular oxidative stress as a combined mechanism for an augmented antimicrobial effect. The opto-chemical method yielded a 6.7-log10 reduction of the mature Staphylococcus aureus biofilms (i.e., approximately 1.0-log10 higher than current requirement of standard treatment). The proposed technique may be a feasible disinfection method for mitigating the risk associated with infection transmission.

Original languageEnglish
Pages (from-to)5736-5750
Number of pages15
JournalBiomedical Optics Express
Volume12
Issue number9
DOIs
StatePublished - 1 Sep 2021

Fingerprint

Dive into the research topics of 'Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model'. Together they form a unique fingerprint.

Cite this