Optimization of recombinant Escherichia coli fed-batch fermentation for bovine somatotropin

Sung Kwan Yoon; Seon Hun Kwon; Myoung Gyu Park; Whan Koo Kang; Tai Hyun Park

doi:10.1007/BF01020836

Optimization of recombinant Escherichia coli fed-batch fermentation for bovine somatotropin

Sung Kwan Yoon
, Seon Hun Kwon
, Myoung Gyu Park
, Whan Koo Kang
, Tai Hyun Park

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batch E. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at μ=0.23 hr^-1.

Original language	English
Pages (from-to)	1119-1124
Number of pages	6
Journal	Biotechnology Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1007/BF01020836
State	Published - Nov 1994

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title = "Optimization of recombinant Escherichia coli fed-batch fermentation for bovine somatotropin",

abstract = "Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batch E. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at μ=0.23 hr-1.",

author = "Yoon, \{Sung Kwan\} and Kwon, \{Seon Hun\} and Park, \{Myoung Gyu\} and Kang, \{Whan Koo\} and Park, \{Tai Hyun\}",

year = "1994",

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AU - Yoon, Sung Kwan

AU - Kwon, Seon Hun

AU - Park, Myoung Gyu

AU - Kang, Whan Koo

AU - Park, Tai Hyun

PY - 1994/11

Y1 - 1994/11

N2 - Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batch E. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at μ=0.23 hr-1.

AB - Optimum specific growth rate for the production of recombinant bovine somatotropin (bST) was investigated in fed-batch E. coli fermentation with a controlled specific growth rate. Maximum specific bST concentration based on cell mass decreases linearly with the controlled specific growth rate. Productivity of bST is expressed by a quadratic equation as a function of the specific growth rate and has a maximum value at μ=0.23 hr-1.

UR - https://www.scopus.com/pages/publications/0028081211

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DO - 10.1007/BF01020836

M3 - Article

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VL - 16

SP - 1119

EP - 1124

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 11

ER -

Optimization of recombinant Escherichia coli fed-batch fermentation for bovine somatotropin

Abstract

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