Optimal First-Line Therapy for Acute Low-Tone Sensorineural Hearing Loss

Seung Ho Shin, Sung Wan Byun, Sohl Park, Eun Hye Kim, Min Woo Kim, Ho Yun Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background and Objectives: We aimed to analyze treatment outcomes following different initial management approaches and confirm treatment regimens for acute low-tone sensorineural hearing loss (ALHL) that would yield the best results. Subjects and Methods: We retrospectively analyzed the medical records of 106 patients with ALHL who visited a university hospital's otology clinic from March 2013 to June 2019. Pure-tone averages at the initial visit and at 2 and 4 weeks after the initial visit were evaluated. Results: Forty-nine patients were enrolled in this study; of them, 41 (83.7%) exhibited complete recovery (CR) at 2 weeks and 43 (87.8%) exhibited CR at 1 month after the initial visit. Regression analysis revealed that CR at 2 weeks after the initial visit was associated with diuretic use [Exp(B): 10.309, 95% confidence interval (CI): 1.007-100]. An initial daily low-dose steroid use was marginally significant [Exp(B): 1.042, 95% CI: 0.997-1.092; p=0.066]. Isolated diuretic use [Exp(B): 25.641, 95% CI: 1.121-90.909; p=0.039] was an independent, good prognostic factor at 1 month after the initial visit. However, other treatment regimens did not affect the final results. Conclusions: A combination of initial daily administration of <30 mg prednisolone plus diuretics was sufficient as the first-line treatment for ALHL.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalJournal of Audiology and Otology
Issue number4
StatePublished - Oct 2021

Bibliographical note

Funding Information:
This research was supported by by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2017R1C1B5017839 for HYL).

Publisher Copyright:
© 2021 The Korean Audiological Society and Korean Otological Society. All Rights Reserved.


  • 0Hearing loss
  • Meniere disease
  • Prognosis
  • Steroids
  • Sudden
  • Treatment outcome


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