Online registry for nationwide database of Helicobacter pylori eradication in Korea: Correlation of antibiotic use density with eradication success

Beom Jin Kim, Chang Hun Yang, Hyun Joo Song, Seong Woo Jeon, Gwang Ha Kim, Hyun Soo Kim, Tae Ho Kim, Ki Nam Shim, Il Kwun Chung, Moo In Park, Il Ju Choi, Ji Hyun Kim, Byung Wook Kim, Gwang Ho Baik, Sok Won Han, Hyang Eun Seo, Woon Tae Jung, Jung Hwan Oh, Sang Gyun Kim, Jun Haeng LeeSue K. Park, Byung Joo Park, Bo Ram Yang, Joongyub Lee, Jae G. Kim

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: The Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. Materials and Methods: We enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through “on-line database registry” from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons. Results: Finally, 6738 patients were analyzed. The overall eradication rate of first-line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H. pylori eradication. Eradication success was significantly associated with younger age, female sex, and high compliance. Regional differences in eradication rates were observed. The yearly use density of clarithromycin increased statistically in seven regions across the country from 2010 to 2015. The yearly use density of amoxicillin in the Gyeongsang and Chungcheong areas was significantly increased (P '.01), whereas that of other macrolides was significantly lower in the Gyeonggi area than in other areas (P =.01). The overall use of eradication antibiotics has increased while the eradication rate steadily decreased for 5 years. However, there was no significant correlation between antibiotic use density and eradication. Conclusion: There was no relationship between the eradication rate and antibiotic use density in Korea.

Original languageEnglish
Article numbere12646
Issue number5
StatePublished - 1 Oct 2019

Bibliographical note

Funding Information:
Funding information This work was supported by a Korean College of Helicobacter and Upper Gastrointestinal Research Foundation Grant.

Publisher Copyright:
© 2019 The Authors. Helicobacter published by John Wiley & Sons Ltd


  • Helicobacter pylori
  • antibiotic use
  • eradication success
  • first-line therapy
  • online registry


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