One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides

Parigi Raghavendar Reddy; Lianji Cui; Jae Sang Ryu

doi:10.1039/c7ra12889d

One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides

Parigi Raghavendar Reddy, Lianji Cui, Jae Sang Ryu

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.

Original language	English
Pages (from-to)	2759-2767
Number of pages	9
Journal	RSC Advances
Volume	8
Issue number	5
DOIs	https://doi.org/10.1039/c7ra12889d
State	Published - 2018

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© The Royal Society of Chemistry 2018.

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abstract = "One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.",

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AU - Reddy, Parigi Raghavendar

AU - Cui, Lianji

AU - Ryu, Jae Sang

N1 - Publisher Copyright: © The Royal Society of Chemistry 2018.

PY - 2018

Y1 - 2018

N2 - One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.

AB - One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.

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U2 - 10.1039/c7ra12889d

DO - 10.1039/c7ra12889d

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JF - RSC Advances

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ER -

One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides

Abstract

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