One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Sung Chun Yu; Yeon Ryu Ka; Ok Ko Young; Yeon Hong Joo; Jongki Hong; Hyunik Shin; Sang Gi Lee

doi:10.1021/jo901642t

One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Sung Chun Yu
, Yeon Ryu Ka
, Ok Ko Young
, Yeon Hong Joo
, Jongki Hong
, Hyunik Shin
, Sang Gi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

(Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

Original language	English
Pages (from-to)	7556-7558
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	74
Issue number	19
DOIs	https://doi.org/10.1021/jo901642t
State	Published - 2 Oct 2009

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title = "One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates",

abstract = "(Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.",

author = "Yu, \{Sung Chun\} and Ka, \{Yeon Ryu\} and Young, \{Ok Ko\} and Joo, \{Yeon Hong\} and Jongki Hong and Hyunik Shin and Lee, \{Sang Gi\}",

year = "2009",

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doi = "10.1021/jo901642t",

language = "English",

volume = "74",

pages = "7556--7558",

journal = "Journal of Organic Chemistry",

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T1 - One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

AU - Yu, Sung Chun

AU - Ka, Yeon Ryu

AU - Young, Ok Ko

AU - Joo, Yeon Hong

AU - Hong, Jongki

AU - Shin, Hyunik

AU - Lee, Sang Gi

PY - 2009/10/2

Y1 - 2009/10/2

N2 - (Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

AB - (Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

UR - https://www.scopus.com/pages/publications/70349467876

U2 - 10.1021/jo901642t

DO - 10.1021/jo901642t

M3 - Article

C2 - 19778084

AN - SCOPUS:70349467876

SN - 0022-3263

VL - 74

SP - 7556

EP - 7558

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 19

ER -

One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Abstract

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